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Generic Inderal, Generic Protonix Online Pharmacy Pricing is the best approach for Comparing prices with your local Pharmacy Pricing.
Biotech, Depression, Drugs
BrainCells Inc. Maps Out Next Steps for Novel Depression Drug
Luke Timmerman 2/2/10
San Diego-based BrainCells Inc. surprised the field of psychiatry last August, when a clinical trial showed that it could relieve symptoms of depression with an odd combination of an anxiety drug and a common dietary supplement. Six months later, the company is in the thick of plotting the next steps to turn this into a potential commercial hit.
In its provocative study of 142 patients, BrainCells showed that a low-dose generic buspirone, an anti-anxiety med, and the dietary supplement melatonin were able to achieve “comparable” effectiveness to standard treatments, known as selective serotonin reuptake inhibitors, according to Mauricio Fava, the vice chair of psychiatry at Massachusetts General Hospital. The company has been pretty quiet since then, but I caught up with BrainCells CEO Jim Schoeneck and chief scientist Carrolee Barlow a couple weeks ago at the JP Morgan Healthcare Conference to find out more about where BrainCells is going to take this drug in the future.
The data to support the BrainCells drug is potentially a big deal both scientifically and medically. The new drug is thought to have a completely different way of working than standard meds, by stimulating the growth of new neurons in the brain, what’s known as neurogenesis. The new mode of treatment could have a big impact on mental health, because an estimated 20 million people in the U.S. suffer from depression, the standard drugs don’t work for everybody, and they can cause side effects like weight gain and sexual dysfunction. The BrainCells combination drug didn’t show any side effects like that, so it might be an important new option for millions.
“The depression data we showed has really been the big story over the past few months,” Schoeneck says.
Before anybody gets too excited, this drug isn’t going to arrive at the corner pharmacy anytime soon. BrainCells still has a lot of work to do before it can leap ahead into a pivotal trial that could win FDA clearance to start selling the drug, code-named BCI-952. The earlier trial involved separate pills containing buspirone and melatonin. That’s not really commercially practical because both drugs are cheap and commonly available as individual components, and it’s hard to make sure patients regularly comply with a two-drug regimen.
Biotech, Depression, Drugs
BrainCells Inc. Maps Out Next Steps for Novel Depression Drug
Luke Timmerman 2/2/10
San Diego-based BrainCells Inc. surprised the field of psychiatry last August, when a clinical trial showed that it could relieve symptoms of depression with an odd combination of an anxiety drug and a common dietary supplement. Six months later, the company is in the thick of plotting the next steps to turn this into a potential commercial hit.
In its provocative study of 142 patients, BrainCells showed that a low-dose generic buspirone, an anti-anxiety med, and the dietary supplement melatonin were able to achieve “comparable” effectiveness to standard treatments, known as selective serotonin reuptake inhibitors, according to Mauricio Fava, the vice chair of psychiatry at Massachusetts General Hospital. The company has been pretty quiet since then, but I caught up with BrainCells CEO Jim Schoeneck and chief scientist Carrolee Barlow a couple weeks ago at the JP Morgan Healthcare Conference to find out more about where BrainCells is going to take this drug in the future.
The data to support the BrainCells drug is potentially a big deal both scientifically and medically. The new drug is thought to have a completely different way of working than standard meds, by stimulating the growth of new neurons in the brain, what’s known as neurogenesis. The new mode of treatment could have a big impact on mental health, because an estimated 20 million people in the U.S. suffer from depression, the standard drugs don’t work for everybody, and they can cause side effects like weight gain and sexual dysfunction. The BrainCells combination drug didn’t show any side effects like that, so it might be an important new option for millions.
“The depression data we showed has really been the big story over the past few months,” Schoeneck says.
Before anybody gets too excited, this drug isn’t going to arrive at the corner pharmacy anytime soon. BrainCells still has a lot of work to do before it can leap ahead into a pivotal trial that could win FDA clearance to start selling the drug, code-named BCI-952. The earlier trial involved separate pills containing buspirone and melatonin. That’s not really commercially practical because both drugs are cheap and commonly available as individual components, and it’s hard to make sure patients regularly comply with a two-drug regimen.
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Right from the start, recognize this: no outside firm knows how Google or any other search engine works. Some search engine optimization (SEO) companies will literally guarantee significant search term ranking within days or a couple of weeks for a brand new website. This is an untrue statement that a truly credible SEO company would not make.
Nor can any SEO expert guarantee you the top results in the search engines for any widely searched keyword phrase unless they are going to buy that term– usually at premium pricing. SEOs that market that type of claim normally select phrases like your company's name or something so obscure that no one is likely to search on it any way. It's just fine for an SEO to make some limited promises, but if they claim they can get definitely get you a number one spot, stay away.
For instance, it's very impressive to come up first on the web (in the first 10 positions) for a popular search term like “mortgage” or even “mortgage discount”. However, if your website is designed such that a search brings up your company's name first on Google – it's really no big deal.
Always ask for explanations where processes or statements are confusing or unclear. If an SEO firm develops deceptive content for you such as “doorway pages”, your site can be permanently removed from Google's index. You are ultimately responsible for online activities and results produced, so it's smart to ensure you understand exactly how the SEO intends to serve you.
Once you have purchased a domain name, you will begin to be contacted by SEO scam firms. Some will just grab your money and simply do nothing, while others can actually prove to be very harmful to your online presence. So it's important prior to hiring an SEO firm, that you definitely ensure your own basic understanding of how this whole SEO service industry works.
Offline, many of these so-called experts frequent small business conventions in search of suckering in non-tech savvy prospects (prey). SEO scams may also come in the form of a letter/email. Some companies deliberately send confusing solicitations. The letters can look legitimate and are usually sent to people who have just purchased a domain. The confusion comes in where the letters look like a bill for SEO services. Just treat them like junk mail – throw them away.
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It has been said that desperate times call for desperate measures, and that is the feeling that most website owners have after they've been experiencing the huge frustrations of trying to get their online businesses to be displayed in the top ranking pages of Yahoo! or Google. Your only option as a website owner who must have a good ranking or else go bankrupt, would be to hire a really great SEO company that specializes in getting a small business like yours a really great ranking at all costs. Here are six ways to make sure you are picking the right company to put you in the league with the big boys of the internet world:
1. IMPLEMENT A GOOD BACKGROUND CHECK ON YOUR POTENTIAL SEO COMPANY This step includes typing the company name in Yahoo! or Google and seeing what kind of negative feedback comes back on the SEO business that you are interested in. I would say that if there are more than six credible instances of irate customers who used this SEO company and were not at all satisfied with the service they provided, definitely start looking elsewhere.
Just make sure you are looking in the right places to get this credible info, because it could be misinformation put out there by the SEO company's main competitors. If you can make a contact with a previous customer, by all means do this first. A first hand testimonial from someone with a similar online business like yours who had a good experience with the SEO company is the best research tool of all.
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4. NEVER USE AN SEO COMPANY THAT USES AUTOMATED SUBMISSIONS No credible SEO company would ever submit your web pages using an automated software. To get a great ranking at Google, for example, there are strict submission guidelines that Google insists on for every page submission. If you use any one of these automated submissions software, you could get a permanent ban from Google, something no business can recover from.
5. IF THEY SAY THEY CAN GET YOU A #1 RANKING AT GOOGLE, STAY AWAY FROM THEM You might think that this claim from an SEO company would be a good thing. Unfortunately, there is not one SEO company around today that would be able to make that claim with even the smallest amount of validity. Even when the keywords that the SEO company is optimizing falls into the category of “rarely used”, there is no way that any company can guarantee you a #1 rank. So when you hear that claim coming out of a customer service rep's mouth, immediately back away from doing business with that SEO company.
6. YOU GET WHAT YOU PAY FOR If an SEO company you are looking into does not charge very much at all for search engine optimization, there must be a good reason for the low cost. Incompetence on the part of the low cost SEO business is generally the reason that a company cannot charge the same rates that a more professional SEO organization can for its superior service. You must be aware that paying a lower fee for search engine optimization will usually mean that you will get a far lower ranking than you would if you went to a far more expensive one.
So before you take out that business checkbook, make sure that you have followed these rules for deciding exactly who should run the very important search engine optimization techniques for your precious web business.
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